Experimental Study Of Normal Threshold Of Hepatic Perfusion Using Multi-slice CT With Deconvolution Algorithm

Purpose: To explore a reliable method to measure the parameters of hepatic perfusion imaging using multi-slice CT (MSCT) with deconvolution algorithm and to determine the normal threshold.Patients and Methods: 21 without liver disease collected from the patients who underwent CT examination for an unrelated cause were included in the study (14 men, 7 women, age range, 20-75 years, mean age, 50 years). The CT examinations were performed on 8 multi slice spiral computer tomography (GE Lightspeed Ultra). On transverse scout images of the upper abdomen, a level was determined at which the liver, aorta, and portal vein were clearly visualized. A nonionic iodinated contrast agent containing 30gI/100ml was administered IV through a 19G or 20G catheter at the start of the CT study. 50 ml of the contrast agent, was injected with a power injector at a rate of 4.5ml/s via an antecubital vein. The subjects kept breathing quietly during the perfusion study. To avoid respiratory motion artifacts, the subjects were clearly informed of a possible flushing sensation during contrast agent injection. The CT perfusion protocol comprised 280 scans that were obtained at the level with the following parameters: 120kVp, 100mA, large field of view, 5-mm slice thickness. The images were transferred to GE AW4.2 workstation for data analysis. Two regions of interest (ROIs) were drawn in the aorta and the portal vein. Three large ROIs were drawn in the right, left liver lobes. The cine full and axial full...