The Characteristic Of Low Body Mass Index Patients With Chronic Obstructive Pulmonary Disease

Objective: To study the characteristic of low body mass(BMI) index patients with chronic obstructive pulmonary disease(COPD)and the correlative factors with their BMI . In order to find a new way to evaluate patient's condition,prognosis and the methods of prevention and management.Methods: A total of 38 patients with moderate-severe stable COPD were enrolled. They were divided into two groups based on BMI = weight / height~2: underweight(UW) group (n=16),BMI<20;normal weight(NW) group(n=22), 20≤BMI<26. All patients were measured body height and weight, recorded smoking pack-years and measured six-minutes walking distance(6MWD). The British Medical Research Council(MRC) dyspnea scale was used to assess the degree of dyspnea and St.George's Respiratory Questionnaire(SGRQ) and Medical outcomes study Short Form 36 item Questionnaire(SF-36) were used for health-related quality of life(HRQoL) evaluation. Patient's fasting venous blood were collected,and then centrifuged and reserved serum. The serum concentrations of Leptin,Ghrelin,TNF-αwere detected by Enzyme-linked immunosorbent assay (ELISA). CRP was detected by immunoturbidimetry. Comparing the two groups results, linear correlation and stepwise multiple regression analysis were used to analysis the relativity between BMI and clinical variables.Results: (1) Pulmonary function:compared with the NW group, the UW group Inspiratory capacity(IC),Forced expiratory volume in one second (FEV1),Vital Capacity(VC),Most ventilate volume (MVV),Peak expiratory flow(PEF) were lower(p<0.05); Residual volume-to-total lung capacity ratio (RV/TLC) was significantly higher(p<0.01). Linear correlation analysis showed that BMI was correlated with the predicted value of FEV1(FEV1.0%),FEV1,...