Study On The Serum Leptin And Nutritional Status Of Chronic Obstructive Pulmonary Disease

Objectives:The aim of this study is①to investigate the serum leptin concentrations of Chronic Obstructive Pulmonary Disease(COPD)and health Chinese people and assess the relationship between serum leptin concentration and fat mass,gender,age,MAC,MAMC,blood gas anlysis,etc.②to analyze the correlation and the interaction of the serum leptin level and the nutrition index.Make basic investigations for further understanding of its physiological functions and effects to human metabolism.Methods:The study population consisted of 31patients with COPD,and 31health controls.We measured the body height,body weight,chest circumference,abdomen circumference,triceps skinfold thickness,etc.And with corresponding formulas calculate BMI,IBW%,FAT%,MAMC,etc.We tested the serum leptin by immunoradiometric analysis.Statistical analyses were performed with SPSS 12.0Results:①COPD group compared with the normal control,their difference among subscapularis skinfold thickness,upper arm middle circumference,BMI,IBW%,arm muscle circumference,serum leptin level have statistical significance.③Most of the index include subscapularis skinfold thickness,triceps skinfold thickness,hematoglobin,chest and abdomen circumference,upper arm middle circumference,BMI,IBW%,arm muscle circumference,serum leptin level except lymphocyte,FAT%were significantly different amang COPD patients and normal control(p＜0.01 or p＜0.05).③Body height,body weight,chest circumference, abdomen circumference,triceps skinfold thickness,skin-fold thickness of subscapular angle,Middle upper arm circumference,BMI,IBW%,MAMC,serum leptin concentrations of patients without malnutrition were significantly higher than patients with malnutrition(p＜0.01 or p＜0.05).④The concentration of serum leptin positively correlated to the chest circumference,abdomen circumference,triceps skinfold thickness,skin-fold thickness of subscapular angle,Middle upper arm circumference,BMI,IBW%,MAMC,(p＜0.01) Conclusions:①The concentrations of serum leptin was significantly higher than normal control,and some index of nourishment such as BMI,IBW%,FAT%,etc.were significantly lower than normal control and Chronic Obstructive Pulmonary Disease patients exist nutritional disturbance②main nutritional index and serum leptin were all significantly higher than malnutrition group,meanwhile it has no significant deviation of most nutritional index between un-malnutrition group and normal control.③The concentration of serum leptin positively correlated to the chest circumference,abdomen circumference,triceps skinfold thickness,skin-fold thickness of subscapular angle,Middle upper arm circumference, BMI,IBW%,MAMC,indicate that the disease of COPD itself has a significant effect on the serum leptin and nutritional index.④The serum leptin level and the serum albumin level showed negative correlation in the COPD malnutrition group.