The Role Of P38 Mitagen-activated Protein Kinase In Brain Injury Following Cerebral Ischemia And The Neuroprotective Effect Of P38 Inhibitor SB239063

Objective: Ischemia, as the most common cause of stroke, is an emergent disease endangering the people's life and health because of its high mortality and serious disability. The mechanism of pathogenesis and pathophysiology after cerebral ischemia is not clear now, which become the focus of neurology.Mitogen-activated protein kinase (MAPK) is an integration point of different signal transduction pathways. Many tyrosine kinases stimulate signaling cascades that lead to activation of mitogen-activated protein kinase (MAPK) pathways. In verterbrates, there are at least four different MAPKs that convey distinct biological responses. P38MAPK plays an essential role in regulating inflammatory responses, cytokine secretion and cell apoptosis. In the nervous system, activation of p38MAPK is closely related to apoptosis and death in response to a variety of pathological conditions. A new way treated ischemic stroke may be opened by inhibiting and regulating the expressation and activity of p38MAPK under the level of singal pathway.