The Experimental Study Of Simvastatin As A New Method To Prevent Delayed Cerebral Vasospasm After Subarachnoid Hemorrhage.

Objective: Delayed cerebral vasospasm (DCVS) is a common, formidable, and potentially devastating complication in patients who have sustained subarachnoid hemorrhage (SAH). It is reported that inflammatory response may play an important role in the development of DCVS. A critical event participating in this response is the recruitment of circulating leukocytes into the inflammatory site. Genes related to inflammation, especially some cytokines are highly expressed in spastic arteries, which suggested that inflammatory response may cause sustained contraction of the cerebral artery. Nuclear factor- k B (NF- k B), a ubiquitous transcription factor, regulates a number of processes and playes a critical role in the inflammation. Since it can modulate some inflammation related adhesion molecules and cytokines, NF- κ B may be critical in DCVS .Recently, Simvastatin is found to have an anti-inflammation effects.In our study, we apply Simvastatin by oral administration to the rabbit model of SAH to prevent DCVS, and then probe into its molecular biological mechanism in order to find out a new method to prevent DCVS .Methods: 64 New Zealand male white rabbits (weight...