Antisense Oligonucleotide Targeting Survivin Induces Apoptosis Of Hepatocellular Carcinoma Cell And Enhances Its Sensitivity To Chemotherapeutic Agents In Vitro

Objective:The hepatocellular carcinoma(HCC) is one of the highest incidence malignant tumor in digestive system. Respecting of the high incidence of hepatitis in our country, the morbidity and mortality of hepatoma have the elevated tendency year by year in recent years. HCC occupied more than 90% in primary hepatic carcinoma. At present, there are no efficacious therapia to cure hepatoma, because it has the bionomics of the powerful infiltration, easy recrudescence and metastasis,and so on. It has becomed the oncological hot topic to research the etiopathogenisis, pathogenesy, bionomics and original therapeutics of hepatocellular carcinoma. Survivin, a novel inhibitor of apoptosis deserves more attention as a selective target for cancer therapy because it is abundantly expressed in a variety of human tumors and is undetectable in terminally differentiated adult tissue. In this study, we investigate the effects of antisense oligodeoxynucleotide(ASODN) targeting survivin on hepatocellular carcinoma cells SMMC-7721 proliferation, apoptosis, and sensitivity to chemotherapeutic drugs.In order to find a new therapeutic way to hepatocellular...