The Effect Of Autologous Bone Marrow Nononuclear Cells And Mesenchymal Stem Cells Transplanted Intracoronary On The Cardiac Structure And Function In Experimental Acute Myocardial Infarction

Objective: Acute myocardial infarction (AMI) is a kind of serious disease that harms human health. Because of the loss of cardiomy.ocytes and contract function, AMI always lead to heart failure in the end. Some treatments, such as thrombolysis, percutaneous transluminal coronary angioplasty (PTCA), transmyocardial laser revascularization (TMR) and coronary artery bypass graft (CABG), can reduce the number of dead cardiomyocytes, but these treatments can not revert this progression. The reason is these treats can not regenerate and resurrect myocardium. In recent year some researchs find that there are some mitosis and cytokinesis around the area of MI, but this phenomema is limited and can not take on the work of myocardium repairment. Nowadays, investigators put forword a measure to solve this problem on cell level, cellular cardiomyoplasty (CCM). They use cells transplantation to replace damaged cardiomyocytes to increase the number of cardiomyocytes, to repair myocardium, to improve cardiac function and to decrease mortality rate. So we have a new choice to treat MI. The materials of bone marrow stem cells are...