Clinicopathological Significance Of The Expression Of CyclinD1,CDK4,p16 And Rb In Colorectal Carcinoma

Objective: To study the clinicopathological significance of the expression of CyclinD1, CDK4, p16 and Rb in colorectal carcinoma. To investigate the correlation of the expression of CyclinD1, CDK4, p16 and Rb with clinical pathological characteristics in colorectal carcinoma . To investigate the corelation between CyclinD1, CDK4, p16 and Rb. Provide abnormality of many genes involved the regulatory pathway of CyclinD1, p16, CDK4 and Rb in the molocular mechanism of colorectal carcinogenesis.Methods: Immunohistochemical technique SP was used to examine the expression of CyclinD1, CDK4, p16 and Rb in 70 cases of colorectal carcinomas and their surrounding tissues (3cm distanced) and (10cm distanced) normal tissues. The levels the expression were analyzed combined with clinicopathological features of the patients including age, the cases, tumor size, loci of the tumor, infiltration depth, differentiation degree, histology type, lymph node metastasis, and Dukes-stages.Results: Buffy color staining found in cytoplasms and/or nucleus was recognized as positive. CyclinD1 and Rb located in...