Study On Efficacy And Safety Of Intensive Lipid Lowering With Atorvastatin In High Risk Coronary Heart Disease

Objective: Coronary atherosclerosis heart disease (CHD) is a disease caused by several risk factors with high morbidity and mortality, especially in the population with high risk factors. Thus, how to prevent and management CHD has been a hot point. The advent of statin brought us a new era for management of CHD. Over the last decade, several large-scale clinical trials have been carried out to test the efficacy of atorvsatatin at 80mg/day, they all showed that atorvastatin of 80mg/day can significantly lower the total cholesterol (TC), low density lipoproteins cholesterol (LDL-C), triglycerides (TG), and small increase high density lipoproteins cholesterol (HDL-C). Accordingly, atorvsatatin at 80mg/day have striking effects in reducing morbidity of CHD, incidence of coronary events and increasing survival rate. More importantly, the whole safety profile of intensive lipid lowering with atorvsatatin is safe. Efficacy and safety of small dose of statins has been estabished in the population in China. However, there is no data of the efficacy and safety of intensive lipid lowing with statins available as yet. This study was designed to determaine the efficacy and safety of 40mg/day of atorvastatin in high-risk...