Effects Of PDGF On Adhesion And Migration Of VSMC

Background: Coronary restenosis is the most frequent complication after percutaneous transluminal coronary angioplasty (PTCA), and effective prevention and cure measures still have lacked at present. There is a common pathological change process that mechanical injuries from PTCA lead to destroy integrity of intimae, make platelet and leukocyte aggregate at the lesion, then various factors release and participate in inducing vascular smooth muscle cell (VSMC) of tunica media phenotype transformation, migration, proliferation and secretion extracellular matrix. These factors facilitate development of coronary restenosis.Inflammatory reaction after injury is an initial factor in development of restenosis. The leukocyte adherence, recruitment and infiltration occur at sites of vascular injury. Vascular cell adhesion molecular-1(VCAM-1) plays a central role in the behavior of leukocyte.It had already confirmed that smooth muscle cell proliferation/migration and extracellular matrix (ECM) deposition played a critical role in development of coronary restenosis. The normal VSMCs reside in tunica media of the artery wall, surrounding by ECM. Through degradation of...