Synthetic Evaluation On The Therapeutic Effect Of Hypertensive Intracerebral Hemorrhage Treated By Different Methods And Pathological Research On The Mechanism Of The Brain Damage After Intracerebral Hemorrhage

Hypertensive Intracerebral Hemorrhage(HICH) is associated with a high mortality and severe disability. The treatment of choice is still controversial and may be surgical or nonsurgical (conservative). And yet the standard therapeutic strategy has not been established. So in the first part the clinical data of HICH patients treated by different methods were collected and their therapeutic effect evaluated by retrospective case control study.Secondary brain damage after intracerebral hemorrhage was considered as the main factor to cause unfavorable prognosis. Some researches discovered that apoptosis are involved in brain damage in the perihematoma region, but its mechanism was not clear. So in the second part, through building experimental intracerebral hemorrhage (ICH) model in rats and collecting clinical pathological specimens, we try to investigate the apoptosis expression in perihemotoma region and also to explore its relationship with Caspase-3 protein expression and excitatory amino acids (EAAs) contents in this...