A Randomized Comparative Study Of The Effects Of Low Molecular Weight Heparin (Fragmin) Or Unfractionated Heparin On Plasma Anti-Xa Activity And Activated Clotting Time During Elective Percutaneous Coronary Intervention

Objective: Unfractionated Heparin (UFH) has been used as the antithrombotic of choice since the adaptation of percutaneous coronary intervention (PCI). Low molecular weight heparins (LMWH), along with UFH have been recommended as the anticoagulants of choice in the management of acute coronary syndrome (ACS) by the recently updated guidelines. This study was designed to evaluate the safety and efficacy of intravenous LMWH in stead of UFH for patients with ACS underwent coronary angiogram with or without PCI, in order to find out an optimal anticoagulation strategy, and to find if the activated clotting time can become an another parameter for monitoring anticoagulation level of LMWH (Dalteparin / Fragmin) in stead of the plasma anti-Ⅹa activity.Methods: This study had a prospective, randomized design. From May. 2005 to Nov. 2005, a total of 62 patients (age 59.11±9.07 years, female, 24 %) with ACS who were planned to undergo one-stage elective PCI were enrolled and...