Association Between Cholesterol And β-amyloid Peptide Of Brain

Objective: Alzheimer's disease (AD) is a kind of regressive disease of central nervous system (CNS). The main pathologic characters in patients brain of AD are senile plaque (SP) including mainly beta-amyloid peptide (Aβ), neurofibr- -illary tangles (NFT) in neurons and extensive reducing or losing of neurons. AD is characterized by the profuse accumulation of insolubleβamyloid (Aβ) peptides. There are multiple factors to affect formation of Aβ. High choleterol is a risk factor for AD. In vivo and in vitro experiment all suggested that the inhibiting synthesis of cholesterol, lowering the level of serum cholesterol or cell membrane cholesterol can reduce generation of Aβand decrease incidence of AD. High cholesterol is a risk factor for AD.All tissues, including brain, can synthesize cholesterol. 3-hydroxy-3-methyl glutaryl CoA reductase (HMG-CoAR) is a rate-limiting enzyme in the course of synthesis of cholesterol. HMG-CoAR inhibitors, termed statins, can inhibit cholesterol synthsis, and they've been widely used in the treatment of hypercholesteremia. Converting cholesterol to bile acid in liver is an important way for body to eliminate cholesterol. A large part of brain cholesterol can be converted by cholesterol...