Expression Of BCSG1 And Survivin And Its Pathological Significance In Breast Cancer

Objective: Breast carcinoma is one of most common malignant tumors in woman. Recurrence and metastasis are the main causes of postoperative death after radical operation for the patients with breast cancer. Up to now, there are still no reliable early predicators for recurrence and metastasis in clinical practice. In the past a few decades, as the rapid development of immunological and molecular biological technologies, the clinical pathological significances of many biomarkers such as, c-erbB-2, P53, uPA, VEGF, muc-1, CD44, maspin, etc, have been throughly studied in breast cancer. Among all these biomarkers, c-erbB-2 is a very good prognostic indicator for breast cancer and has been used as the target molecule in the monoclonal antiboby target therapy. Thus, it is very important to further explore other early predicators for the reccurrence and metastasis of breast cancer.BCSG1 gene is identified and cloned by direct-differential cDNA sequencing approach and defined as a new family member of human brain SNCs (neural protein synuclein). It has been found that this gene expressed highly in invasive breast carcinoma, while nearly no positive expression in normal breast...