The Construction Of HIV-1 Recombinant Adenovirus (Modified Type, Wild Type) And The Comparison Of Their Immunogenicities

HIV is a Retroviridae virus,It causes acquired immunodeficiencysyndrome,(AIDS) .This is one kind of taking the whole human's immunitysystem serious harm as the main characteristic communicable disease. Atpresent,AIDS by 16,000 people/Day speed in world dissemination,Safelydevelops, effective, the inexpensive vaccine is a best strategy to control theHIV. The existing of many HIV candidate vaccines all may induce organism toproduce the immune antibody,But only depends on humoral immunityresponse not to be able to cause organism to resist the HIV infection,Alsocannot slow down disease course of an illness,More and more researchesindicated,Cellular immunity especially CD8 + T cell lies between in particularthe cell toxic T lymphocyte which leads (cytotoxicTlymphocytes,CTLs)responded in aims at the function which HIV in the immunity displays to bemore important than the neutralization antibody response,Specific CTL mayprevent the infectious HIV in the intercellular space dissemination,Thus theideal AIDS vaccine ought to be able to stimulate organism to have the CTLresponse and the neutralization antibody response at the same time.HIV-1;modgagpol;wtgagpol;Adenovirus;Humoral immune response;CTL;ELISPOT...