The Comparative Study On The Effect Of Suanzaoren Decoction And Zhushaanshenwan Decoction On The Sleep Phase Of Insomnia Rats

As an important physiological phenomenon, sleep has an important effect on people's life and health. Good sleep will make us induce tiredness and make people refreshed, so more and more people have drawn attention to the problem of sleeping quality. However, along with the rapid rhythm of modern social living, the exaggeration of the work pressure. Insomnia has been a common disease and some other diseases' reason.There is unique recognition on sleep and insomnia in the Traditional Chinese medicine. According to the clinical data observed by the Traditional Chinese Medicine, it treats mainly sleep-disorder somnipathy with two kinds of Chinese medical prescriptions, tranquilizing prescription with heavy herbs and for supplementing. It could have been proved through the clinical practice for several thousand years that there is unique curative effect on improving sleeping, enhancing sleep quality with the Chinese medicines and compounds.We adopted the experimental method of PSG and electric stimulation to tempt the insomnia of rats. Through the analysis of EEG, we assumed effect of the Suanzaoren decoction and Zhushaanshenwan decoction on the sleep phase of insomnia rats and compared the two experimental results.The results showed that the Suanzaoren decoction of three different doses all could obviously decrease the duration of W and increase TST. Above this, low dose of it had an effect on increasing SWS₁, normal one could increase SWS₁ and SWS: and high dose of it could increase SWS₂. Normal and high doses of Zhushaanshenwan decoction can decreased the duration of W and increase TST. Low dose of it had an effect on increasing SWS₂, normal dose can increase SWS₁ and SWS₂, and high doseof it could increase not only SWSj and SWS2, but also REMS.According to the comparative and analysis of Suanzaoren decoction and Zhushaanshenwan decoction, the results expressed that low dose of Suanzaoren decoction was better than Zhushaanshenwan decoction in decreasing W and increasing the duration of SWSj and TST, but not better than Zhushaanshenwan decoction in increasing SWS2;normal dose of Zhushaanshenwan decoction was much better than Suanzaoren decoction in decreasing W, increasing SWSiand TST, and both of them had effects on increasing SWS2;high dose of them both have effects on decreasing W and increasing SWSi, TST, and Zhushaanshenwan decoction was much better than Suanzaoren decoction in increasing SWSi, SWS2 and REMS.