A Study Of Matra Metalloproteinase-2 In Bladder Carcinoma

Part â…  Expression of matra metalloproteinase-2 and the potiented clinical implications in human bladder transitional cell carcinomaOBJECTIVE:To investigate the expression Of matra metalloproteinase-2 in bladder transitional cell carcinoma (BTCC) and go further into its possible clinicopathological significance. METHODS: Expressions of MMP-2 and VEGF (vascular endothelial growth factor) protein were investigated by means of immunohistochemistry in 57 bladder transitional cell carcinoma-tissues and 12 normal bladder tissues. The relationship between MMP-2 expression and various clinicopathological parameters including pathological grade and clinical stage was analyzed and the correlation between MMP-2 expression and VEGF expression was also analyzed.RESULTS: immunohistochemicaly, Over-expression of MMP-2 was frequently (28 of 57 cases, 49. 12%) detected in BTCC , whereas no MMP-2 expressions in the 12 normal bladder tissues. MMP-2 expression was significantly associated with invasive bladder cancer (Tis-T₁ versus T₂-T₄,P = 0.020)and with increased pathological grade. VEGF expression was also significantly associated with invasive bladder cancer , but not with increased pathological grade. There was a significantly correlation between the expression of MMP-2 protein and the VEGF protein expression (r = 0.695, P < 0.001).CONCLUSION: Expressions of MMP-2 protein is closely correlated to invasion of BTCC. MMP-2 may play a critical role in occurrence and development of bladder carcinoma. MMP-2 has a intimate relationship...