| Diabetic nephropathy is a serious cap vascular complication of diabetes. It is a very important cause bringing about the terminal stage of nephropathy. The pathogenesis of diabetic nephropathy is not clear, it is generally considered that diabetic nephropathy is the outcome co acted by hereditary factors and environmental factors, and it is also interrelated with the synergy of Hyperglycemia, metabolic disturbance of polylol- phaseomannite, oxidizes stress, abnormality of hemodynamics, abnormality of zymoplastic mechanism, nonenzymatic promoted glycosylation. With the development of immunohistochemistry technique, the function of connective tissue growth factor (CTGF) in the outbreak of diabetic nephropathy is attached great importance to increasingly and has become a hot issue. Recently, research on the relativity of ICAM-1 expression and diabetic nephropathy has been a new breakthrough of the research on the pathogenesis diabetic nephropathy.The bintraperitoneal injection of (STZ) was conducted to made models of diabetic rats within a short period of time and impairment of diabetic nephropathy occurred after that. This article aims at discuss the expression of CTGF and ICAM-1 at the early stage of diabetic nephropathy and the mechanism of the curative effects of Qimu kidney tonifying decoction on diabetic nephropathy.Objective: To discuss the expression of CTGF and ICAM-1 in the...
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