Study Of Caveolin-1 Expression During The Recovery Phase Of Gentamicin-induced Acute Tubular Necrosis In Rats And Its Mechanism

Objective: Acute renal failure (ARF) is the rapid breakdown of renal function that characterized by a decrease of glomerular filtration rate (GFR) and high levels of blood urea nitrogen (BUN) or serum creatinine (SCr). It has been well known that the acute tubular necrosis (ATN) is the most common event of ARF, induced by ischemia injury and nephrotoxic injury. The research has indicated that ATN could be triggered by both many of intrinsic pathophysiological processes and lots of chemicals including some present marketing drugs.Aminoglycosides is the most common antibiotic effectively used in preventing gram-negative infection diseases and tuberculosis. However, its clinical utilization is limited because of the serious nephrotoxicity, mainly resulting in proximal ATN and remarkably decline in GFR. On the other hand, the recovery mechanisms of aminoglycosides-induced ATN remained poorly understood.Recently, it has been recognized that there are caveolae typically identified as flask-shaped invaginations occurring in the cell plasma membrane and enriching with multiple signal molecules, as centre of protein and lipid signaling. Many studies have indicated that caveolin-1, a marker protein of caveolae, could interact with various signaling molecules by the scaffolding domain, so as to regulate many pathologic and physiologic processes. It has been well established that tubular endothelial...