Study On Gastrointestinal Protection In Cardiopulmonary Bypass Surgery

Gastrointestinal complication has a high mortality after cardiac surgery. The digestive complication caused by cardiopulmonary bypass has a rate about 0.5%-3%. The incidence seems very small, but when it happens the mortality may be as high as 92%-94%. There are several kinds of digestive complication after cardiac surgery with CPB, such as alimentary tract ulcer, hemorrhage, perforation, pancreatitis, cholecystitis, necrosis and obstruction of small intestine, hepatonecrosis and so on. Alimentary tract hemorrhage has been reported more than others because of its obvious signs. Alimentary tract hemorrhage and perforation often take place in stomach and duodenum that have already has multiple ulcers. Most scholars think that when human body in stringent state, such as shock, pyemia, it may cause hypothalamus' functino disorder. Then there will be more adrenocorticotropic hormone secreted, and under the effect of ACTH, the secretion of gastric juice increased, that may lead to gastric mucosal erosion and ulcer. Stress ulcer(SU) is an acute gastric mucosal process which has an character of gastric mucosal erosion or exulceratio simplex. It can also induce acute upper gastrointestinal bleeding. In stress state, the leval of catecholamines...