Expression Of NRAGE Gene In Gastric Carcinoma And Its Regulation Role In Apoptosis

It has been demonstrated that tumorigenesis and its development is associated with concomitance of multifactors in longterm. Also the progress of tumorigenesis is regarded as sophisticated multi-stages biologically activation of oncogenes and inactivation of tumor suppressor genes leads to hyperplasia and poor differentiation of cells. Tumorigenesis is not only related to the growing speed of cells, but also to the mortality speed of cells according to recent researches. The defect or block of apoptosis is also an important factor that results in the occurrence and development of tumor. So cancer is the disease of abnormal proliferation and differentiation of cells, and the disease of abnormal apoptosis. Gastric cancer are one of the most common malignancies in Chinese population. In1999, NRAGE gene was reported by Pold and Salehi. it is the new membe of Melanoma antigen family (MAGE). It's lecated on Xp11. 23 chromosome. Coding protin is 778 amino acids. Molecular weight is 86kDa. The study demonstrated that the NRAGE geneinduced apoptosis. It played potential negative role in cancer metastasis. There are no reports about the relationship between NRAGE expression in gastric cancer and apoptosis.