Myeloperoxidase And Glutathione-S-transferase P1 Polymorphisms Associated With The Risk Of Lung Cancer

Lung cancer was one of the most common malignant tumors. The incidence and mortality of lung cancer in China have increased rapidly in recent years and the speed was in the first place in malignant tumors. While it is well recognized that 80%~90% of all lung cancer is attributable to cigarette smoking, only 15% of all smokers develop this disease. It suggests that there is great individual variation in susceptibility to lung carcinogens. It is hypothesized that a large proportion of lung cancer susceptibility is determined by the balance between an individual's capacity to activate and detoxify carcinogens for tobacco smoke.Myeloperoxidase (MPO) is released from neutrophils in lung tissue in response to exposure to various pulmonary insults, including tobacco smoking. This enzyme is involved in the activation of an intermediate metabolite of benzo(a)pyrene to the highly reactive benzo(a)pyrene diol epoxide. The -463G→A polymorphism has been identified in the promoter region of the MPO gene. The A allele is associated with a decreased transcriptional activity attributable to the disruption of a SP1-binding site. We therefore examined whether carriers of the A allele may be at reduced risk of lung cancer.Glutathione transferases (GSTs), a multiple gene family of phase II enzymes, catalyze detoxifying endogenous reactions with glutathione and protect cellular macromolecules from damage caused by cytotoxic and carcinogenic agents. Glutathione S-transferase p1 (GSTP1), the most abundant GST isoform in the lung,...