Relationship Between The GSTP1 Genetic Polymorphism And Susceptibility To Lung Cancer In Xinjiang Uygurs And Hans

Objective:To study the association between glutathione S-transferase P1 and lung cancer in Xinjiang Uygurs and Hans. Methods:A case-control study was conducted, PCR-restriction fragment length polymorphism (PCR-RFLP) analysis was used for the polymorphism of GSTP1 gene in 120 patients from Uygur and 128 from Han Ethnic as case group,120 healthy people from Uygur and 134 from Han Ethnic group. At the same time, case-control study was performed to analyze genotype frequency and difference between Uygurs and Hans nationalities. Results:(1)The genotype of the GSTP1 gene rs1695 variants were in Hardy-Weinberg equilibrium in both Case and Control subjects. (2)In Uygur populations, genotype of GSTP1 at rs1695 site showed no significant differences between Case and Control groups (P>0.05). In Han populations, there was significant difference between two groups (p<0.05).(3)In Han populations, the difference of the genotype frequency GSTP1 at rs1695 site successed to reach statistical significance both in lung squamouse-cell cancer and lung adenocarcinoma cancer(P<0.05). However, there was no difference in Uygur populations(P>0.05). The individuals with G allele had increased risk of developing lung cancer in Han populations by stratifying smoking. (4) In the Case and Control groups, AG and GG genotype frequency of Uygur were higher than frequency of Hans. But the distribution of genotype of GSTP1 did not differ significantly between Case subjects and Controls both in Uygurs and Hans(P>0.05). Conclusion:The genetic polymorphism of GSTP1 was associated with susceptibility to lung cancer in the Han population and has no association in the Uygur population, this relationship varied among different ethnic groups.