Overexpression Of 5-lipoxygenase, Cyclooxygenase-2 MRNA And VEGF In Human Esophageal Squamous Cell Carcinoma And Their Relationship With Angiogenesis.

Background/Aims Esophageal cancer is one of the malignant tumors severely threatening people's life and heath in China, approximately 150 thousand patients die of it each year. Among them 90% are squamous cell carcinomas. The death rate is due mainly to its potency of invasion and metastasis. Thus, it is very important to further understand the detailed information on the invasion and metastasis mechanism of esophageal squamous cell carcinomas (ESCC) in order to look for newer and better therapic targets.Results of epidemiological research have indicated that: regular and long-term intake Aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) can decrease the incidence rate of many digestive tract tumors. The possible mechanism is to inhibit the cyclooxygenase pathway of arachidonic acid (AA) metabolism. But more and more researches show that: except for cyclooxygenase pathway, lipoxygenase pathway is another key pathway of arachidonic acid metabolism, which also plays an important role in the progression of tumors.5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) is respectively the...