The Role Of Stromal Cell-derived Factor 1 In The Process Of Bone Marrow Stem Cell's Homing

Background and objectiveWith the development of quality of life, coronary heart disease(CHD) increases quickly and becomes a major cause of morbidity and mortality around the world. The most serious type is acute myocardial infarction which will lead to myocardium injure even loss of the ability of contraction and relaxation. Thus, in a substantial proportion of patients who experience acute myocardial infarction, congestive heart failure(CHF) subsequently develops largely as a result of left ventricular remodelling. This process involves myocardial thinning, dilation, and function decreased, and it ultimately leads to death. All these attribute to congestive heart failure.Therapeutic advances have mainly been targeted at restoring antegrade perfusion in the infarct-related artery including medication ,intervention and bypass operation but it seems to only effective to some patients. Now one novel way to treat this process after myocardial infarction is cell therapy. Cellular transplantation has focused on use of various cell types, including differentiated cells such as skeletal myoblasts, cardiac myocytes, smooth muscle cells, cardiac fibroblasts, and bone marrow stem cells (BMSCs). Since skeletal myoblasts and smooth-muscle cells cann't be integrate with normal myocardium in structure and function. So current research is focused on bone marrow stem cells. BMSCs possess...