A Study On The Expression Of DPC4 And Ki67 In Pancreatic Carcinoma

Background and ObjectiveThe pancreatic carcinoma is a common malignancy tumor with increasing incidence rates in the world. Most patients have the distant metastasis when they are in final diagnosis. The five-year survival rate is less than 1%. In order to improve its curative effect and prognosis, it is very important to explore the mechanism of the pancreatic carcinoma.It is clear that antioncogene's mutation, deletion or inactivation plays an important or even crucial role in the pancreatic carcinoma at present. DPC4 (deleted in pancreatic carcinoma locus4) gene recently discovered is like this. The deletion or mutation of DPC4 is detected in kinds of tumors, such as pancreatic carcinoma, colon carcinoma, gastric carcinoma and breast carcinoma. DPC4 gene can not only suppress the development but also enhance the apoptosis of tumor cell with the deletion of DPC4 gene. About 50% DPC4 alters in pancreatic carcinoma, among which 30% is pure deletion, and 20% mutation. But the inactivation of DPC4 gene is always less than 10% in other tumors. It shows that DPC4 gene is the speciality of pancreatic carcinoma. So the study on the role of DPC4 in pancreatic carcinoma has been a focus. Detecting DPC4 gene can let us comprehend the biological behavior of pancreatic...