The Expression Of Somatostatin Receptor2,VEGF-C And Its Receptor FLT-4 In Colorectal Carcinoma And Its Implication

Backgroud and Objectives Colorectal carcinoma is one of the most common gastroenteric malignant disease, with the feature of lymph node metastasis in early time, which is closely associated with the prognosis of patients with colorectal carcinima. However, it is still uncler about the mechanisms of tumor cells migration and metastasis.Somatostatin (SS) is a kind of hormone widely distributed throughout the body. SS acts as an important regular of endocrine and nervous system function by inhibiting the secretion of several other hormones such as growth hormones, insulin, and gastric. SS exerts its biologic action by binding to specific high-affinity receptors on the cell surface. There are now five known somatostatin receptors (SSTR1~SSTR5), SSTR2 is predominantly expressed in a majority tumors, and SSTR2 is the primary subtype in halting cancer cells' growth.Lymph node metastasis is an important prognostic factor of colorectal carcinoma. Recently, many experimental studies indicated lymphangiogenic factor C could stimulate lymphangiogenesis in tumors by binding to its receptor FLT-4 on the lymphatic endothelial cells and induing proliferation and growth of new lymphatic capillaries, then enhance the incidence of lymph node metastasis .So, the signal pass of VEGF-C/FLT-4 is important to lymphatic metastasis and lymphangiogenesis.In this study, immunhistochemistry was used to investigate the expression of...