A Study On Levels Of Plasma Platelet-activating Factor In Different Neonates

[Objective] To study the levels of plasma platelet-activating factor (PAF) in premature infants and normal full-term neonates and its relationship with gestation or hypoxic-ischemic encephalopathy (HIE). [Methods] The plasma PAF from 73 premature infants and 40 full-turm neonates were measured by "Sandwich" ELISA, comparing with the differences in levels of PAF in different neonates with mild hypoxic-ischemic encephalopathy (HIE) to moderate and sever HIE, and explore the relationship between PAF and birth weight or gestational age. [Results] The PAF levels in premature infants are significantly lower than those in normal full-term neonates (9.44±3.31pg/ml vs 44.07±12.01pg/ml, P<0.001). In premature infants, PAF levels were positively related to birth weight(r=0.536, P<0.001)and gestational age(r=0.557, P<0.001). In premature infants, the PAF levels in mild HIE were significantly lower in sever HIE (12.72±5.79pg/ml vs 137.18±59.22pg/ml, P<0.001) and higher than non-HIE(12.72±5.79pg/ml vs 9.44±3.31pg/ml P<0.05). In full-term neonates, the PAF levels in mild HIE were significantly lower in moderate and sever HIE (67.29±16.16pg/ml vs 165.82±33.10pg/ml, P<0.001) and significantly higher than non-HIE(67.29±16.16pg/ml vs 44.07±12.01pg/ml, P<0.001) [Conclusion] Obviously lower levels of PAF in premature infants indicate that PAF participate in mature process of premature...