The Role Of Oxidative Stress In Hormesis Induced By Sodium Arsenite In Human Embryo Lung Fibroblast Cells

Hormesis or stimualting effect induced by environmental agents is a dose-response phenomenon characterized by a low-dose stimulation and a high-dose inhibition when body exposuring environmental agents. The curve of hormetic dose-response relationship is a P-shaped or a U-shaped curve. Recently, Calabrese and Baldwin et al have suggested that the majority dose-response modes caused by environmental agents may not be the threshold mode nor the mode of non-threshold linear, but rather hormesis mode. Implicating the new theory of hormesis would cause that the chief principle of toxicology should be rethinked and many territories of environment, medical, public health should be changed.The effects of sodium arsenite on body are very multiplicity. Many results indicate that sodium arsenite of high concentration may induce the multiple injuries and cancers. There are little reports about the effects and mechanisms induced by sodium arsenite of low concentration. Some experiments have demonstrated that the animals are damaged by arsenic deficiency. It has been approved that the arsenic as food additives may improve the growth and...