| Background: Myocardial cell apoptosis is one of early characteristics of reperfusion injury, it probably plays a crucial role in the pathogenesis of myocardial ischemia and reperfusion injury. Previous studies have demonstrated that heat shock pretreatment results in the induction of heat shock protein70 (HSP70) and can confer protection against ischemic reperfusion injury. Several studies have also demonstrated that great deals of reactive oxygen species (ROS) such as O2-, H2O2 and HO· are produced, which are thought to be the main reason for the acute cardiac injury. ROS are newly discovered play a critical role in the myocardial protection caused by heat stress pretreatment. By measuring myocardial contractility, leakage of CK-MB and percentage of the infarct zone, etc. in the isolated rat hearts pretreated by heat stress and N-2-mercaptopropionyl glycine (MPG, a synthetic antioxidant) , the purpose of this study is to investigate the regulatory effect of heat stress pretreatment on myocardial apoptosis mechanism, ROS's role in this protection and their relationship with HSPs.Methods: Wistar rats were divided into 5 groups: the normal control group (NC,...
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