Effects Of Total Glucosides Of Paeony On The Relationships Between The Two Types Of Synoviocytes From Rats With Collagen-induced Arthritis

Rheumatoid arthritis (RA) is the most common disease with autoimmune and inflammatory features, affecting 1% population. The main pathological changes of RA include synovitis and pannus formation, which lead to cartilage erosion and articular destruction. Increasing evidences show that synoviocytes mainly including macrophage-like synoviocytes (MLS) and fibroblast -like synoviocytes (FLS), are the ultimate effectual cells of these pathologic changes. Up to date, the cause of RA is not fully understood. Although there are a few anti-rheumatic drugs showing effectiveness on treating RA, their side effects and toxicity call for new and more effective natural drugs.Total glucosides of paeony (TGP) is an active compound extracted from paeonia lactiflora Pall, a Chinese traditional herbal medicine. It has anti-inflammatory, analgesic and immunoregulatory effects, and it has been approved to enter market for RA as a disease- modifying drug. This study investigated the therapeutic effects of TGP on rats collagen-induced arthritis (CIA) and its relative mechanisms on synoviocytes. Thus, this study would offer theoretic basis not only to further elucidate the pathomechanism of...