| Objective To study the effect of environmental lead pollution on offspring development (growth and development of fetus in uterus, physical growth and intelligence development of offspring).Method Prospective cohort study was followed-up among the newly-wedding couples with the intention to pregnancy and living around a lead and zinc smelt factory from Dec. 1996 to Dec. 1998 until delivery, then their offspring. Meanwhile, we assayed the contents of lead, cadmium, zinc, copper and calcium in baseline blood, mid-pregnancy blood, umbilical cord blood, blood of infants.Result (1)Geometric mean of MBBLL , FBBLL , IBLL, CBLL, UCBLL, MPBLL, were 62.71 ±2.18 μ g/L, 72.93 ± 2.06 μg/L, 91.93 ± 1.58 μ g/L , 130.39±1.88μg/L, 54.32 ±2.11 μ g/L,50.93± 1.95 μ g/L,respectively.The proportion that BLL were higher than 100μg/l were32.38%, 38.09%, 45.30%, 43.03%, 10.20%,9.68%. respectively. Infants BLL increased gradually with age, BLL were higher for boys than for girls.(2) The Z score for infant height , chest circumference, growth rate in stature of infants in high group are lower than normal lead group in female baseline blood. Birth weight and head circumference of neonate, the Z score for infant chest circumference, growth rate in stature of infant in high lead group is lower than normal lead group in male baseline blood.(3)The single correlative and the multiple stepwise regression analysis showed that there was negative association between physical indicators of neonate ,the Z score for infant physical growth indicators and growth rate in stature of infant and different blood lead level. (4)In 161 infants, the incidence of abnormal behavior problems was 16.1%. The scores of delinquent and abruption in boy were significant higher than those in girl, while the scores of depression and social withdrawal in girl were higher than...
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