The Effect Of GB On Glial Cells After Spinal Cord Injury In Rats

After spinal cord injury(SCI),the injured nerve tissues had a series of progression and self-destruction processes such as haemorrhage, oedema, neuronal degeneration, nerve cell apoptosis,that is secondary spinal cord injury.There are many theories about the mechanism of secondary spinal cord injury, for instance: theory of microcirculation disturbance, theory of oxyradical and lipid peroxidation, theory of ion internal environment, theory of neuropeptide, theory of nerve dystrophy and so on,but the theory of inflammatory immune reaction is a hot spot for people all the time.SCI caused severe inflammation, including the activation of relic glial cells, infiltrating of surrounding inflammatory cells (neutrophil, monocytes) and so on.The inflammation after SCI maybe induced the formation of scar tissues and the necrosis and apoptosis of nerve cells and oligodendrocytes thus block the recovery of neurofunction after SCI. The experimental and clinical SCI indicated direct or indirect inhibit inflammation could lessen neurofunctional disturbance after SCI. Up to now, the precisely mechanism of inflammation after SCI has not been fully understood.To further understand the mechanism of inflammation after SCI pathophysiology will be beneficial to produce effective prevention and cure measurement and improve functional restoration after SCI.Ginkgolide B is one of the main active components of ginaton. And it is the most effective antagon of platelet activating factor (PAF). PAF is an important phospholipid inflammatory factor,it can promote polycyte aggregation, attachment, activate monocyte , macrophage, leukomonocyte, produce various kinds of cytokine, strengthen permeability of blood vessel, expand inflammatory reaction ,and through promote thrombogenesis, depress cerebral blood flow, aggravate brain oedema, to...