| Objective By observing the changes of neuroethology and morphology , to confirm that after chronic compression , the dorsal root ganglion of the rat was injured . Then the mRNA expression alteration of the TRAAK channel in the chronically compressed dorsal root ganglion was studied, to explore the neuroprotecetive effect of the TRAAk channel after the nerve system was injured .Methods 49 adult , male Wister rats were randomly classified into seven groups , of which 7 were unoperated control group , 21 were experiment model group and the rest 21 were sham-operation group . In the experiment model group , a U shape steinless rod was inserted into the right intervertebral foramina of the lumber 4 , 5 and 6 . The sham-operation group' surgical procedure was identical to that of the experiment model group but without injury to the dorsal root ganglion , and no operation was performed to the unoperated control group . First , the motor function , latency for thermal pain withdrawal and mechanostimulation pain threshold in the affected hind limb of the rats were studied on 10th , 20th and 30th after injury . Next , to observe the dorsal root ganglion by the light microscope after 10d, 20d and 30d respectively. And finally, the mRNA expression alteration of the TRAAK channel in the dorsal root ganglion was detected by reverse transcription polymerase chain reaction .Results The experiment model group presented significant hyperalgesia behavior after injury, as compared with those in the sham-operation group. On post-injury 10 days and 20 days, there were...
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