| Objective: BC (breast cancer) is one of the most popular malignant tumors. it was looked as a disease in hole the body, once it was happened. On the other hand breast cancer cells can spread all over the body at early time, BM (bone marrow) is the usually part of the body in the BC metastasis. About 40% of BC patients have the failure of treatment because of metastasis in 5 years, but almost 80% of BC patients have no signs of distant metastasis before be diagnosed. BC is the second agent which results in death because of malignant diseases. The disease incidence shows me more adscendent tendency, it is about 50% that the percentage of being induced the failure of treatment by distant metastasis. The form of real metastasis needs a process,and micro metastasis is the hypothesis of metastasis . Micro metastasis is a certain amount of remaining tumor cells of being detected by microscope or deutomicroscope in various kinds organic tissues , body fluids and cellular transplants. One or several cells is not the micro metastasis, but the disseminateion of a small amount liberation cells. The liberation cells can become the real metastasis after sticking on and effusing out of vessel wall and the hyperplasy in the tissue out of vessel. In the procedure,we can find two accompany phenomena that are base material reaction and neovascularity. Most of liberation tumor cells in blood will be killed by organism and only a little cell will form micro metastasis. BM is the most easily part to metastasis on BC patients, the most popular methods are IHC , ICC and molecular biology ,the RT-PCR is the...
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