The Experiment Research Of PYK2 And GLUT4's Function On Insulin Resistance

Background:Obesity is the most familar cause of insulin resistance ,while insulin resistance is the common pathologic base of "insulin resistance syndrome"such as diabetes, hypertension,coronary heart disease,et al. In recent years,insulin resistance has become the research hotspot in many medical fields,especially the mechanism and the interference measure.It is helpful to find available means to improve insulin resistance. The glucose transport protein-4( GLUT-4) acts as the main carrier to conduct and regulate the glucose into cell, the main expression is in the myocardial, the fat organization, the skeleton muscle etc., its abnormality of the activity and the ability of transiting cause the insulin resist. The research express that many factors can influence the activation and transit of GLUT4 through phosphatidylinositol 3-kinase (the PI3Ks) or stimulating the pathway including p48 MAPK. The PYK2 genes which can code protein tyrosine kinase is firstly cloned and discovered by Lev and other people in 1995 , the PYK2 protein have 48% same amino acids with focal adhesion kinase (FAK), it complete the function of conducting signals through interacting with the different signal molecule in the cells of different type. The PYK2 can participate the regulation of PI3Ks, can also activate MAPK signal pathway. The PYK2 can participate the activation of the PI3Ks and MAPK,and then two materials can adjust the activity and transiting of GLUT4. So PYK2 may regulate GLUT4 through the PI3Ks and MAPK to participate the occurrence of insulin resistance in the skeletal muscule.Objectives:...