The Relationships Between The Higher Expression Of TSP-1 And Renal Interstitial Fibrosis As Well As Peritubular Capillary Loss In Chronic Aristolochic Acid Nephropathy

BACKGROUNDAristolochic acid (AA) belongs to nitrophenanthrene carboxylic acid compound. It consists mainly of AA I and AA II, which differs from AA I with the absence of a methoxy group. AA mainly consists in Chinese herbs such as Aristolochia manshuriensis Kom(guan mutong) and Aristolochia fangchi(guang fangji). In 1964, Wu songhan reported the first case of acute renal failure after taking a large dose of mutong decoctum. Chronic progressive renal failure after taking slipping pills containing aristolochia fangchi was firstly reported by Belgians in 1993.Therefore they named the disease Chinese herbs nephropathy (CHN).Domestic scholars suggested that Aristolochic acid nephropathy(AAN) should be a right term.According to the clinical and pathological manifestations of AAN, we classified this disease into three forms: acute AAN, renal tubule functional disturbance AAN and chronic AAN(CAAN).The patients suffered from CAAN undergo progressive deterioration of renal function with chronic hypocellular renal interstitial fibrosis in pathology, which is almost irreversible. Hence CAAN is the most destructive form of AAN. The pathogenesis of CAAN includes different viewpoint, such as hypothesis of cytotoxin, renal hypoxia, immunoreaction and AA-DNA adducts. So far there is not a common one. Therefore it is essential to carry on the related studies.Apparent evidences showed that the loss of renal microvascular was correlated with the progression of kidney diseases, especially in the remnant kidney and the...