The Effects Of Collagen Sponge On Mandibular Distraction Osteogenesis In Goat Model

[Objective]To establish a goat model for mandibular distraction and study the effects of collagen sponge on the early distraction osteogenesis, and offer a instruction for the clinic.[Methods]Six goats were used in this study. Osteotomy was performed in the mandibular and then the distractor was placed. After 4-day latency, the goats were distracted with 0.5mm twice per day for 10 days followed by a consolidation period. The distracted mandibles were harvested after 2,4,6,8 weeks of consolidation and the appearance of samples, radiological changes, bone mineral density (BMD), bone mineral content (BMC) and histology were examined.[Results]The experimental procedure has been well tolerated by all animals and the expected distraction length was successfully achieved; the early osteogenesis of the experimented is obviously better than the contrastive of the same time; the osteogenesis of the lingual is also better than the buccal.[Conclusion]The goat is a perfect mandibular distraction model, and it should be effective for further clinical application and investigations. Collagen sponge may be effective in the early osteogenesis of bone distraction and could shorten the consolidation period; the protected periosteum and the abundant blood are also helpful for the osteogenesis.