The Expression Of IGF-1 On LVRM In Rats After Myocardial Infarction And Drugs Interference

Objective:To observe the suppressing effect of valsartan and captopril on expression of insulin-like growth factor-1(IGF-1) in cardiac myocytes of rats after myocardial infarction. To further study the correlation between IGF-1 and the rennin-angiotensin system (RAS) and the molecular mechanisms of LVRM after MI and guide clinical practice.Methods:MI models were made in SD rats by ligation of the left anterior descending coronary artery. Rats with extensive MI were randomized to treat with placebo,Captopril or Valsartan(100mg/kg body per day or 15mg/kg body per day) as via gavage for 8 weeks starting on the 3rd post-operation day . There were four groups: Sham group (n=10), MI group (n=10), Captopril group (Cap group n=9) and Valsartan group (Val group n=10). Left and right ventricular weights, index of weight, cardiac hydroxyproline and collagen content of four groups were recorded after 8 weeks. The mRNA levels of IGF-1 were detected by RT-PCR. The expression of AT1,PKC and IGF-1 protein were detected by immunohistochemistry.