Study On Mobilization Of Angelica Polysaccharides On Hematopoietic Stem Progenitor Cell In Mice And Hematopoietic Reconstruction With Hematopoietic Stem Progenitor Cell Transplantation

There are thousands of years that Angelica is an important Chinese crude drug to nourish the blood and promote blood flow.Modern empirical studies have showed that the chemical composition of angelica is very complex,and Angelica polysaccharides(APS)is one of the main chemical composition in it. The past researches discovered that APS could obviously promote the proliferation and differentiation of BFU-E,CFU-E,CFU-GM and CFU-MK in health and anaemic mice.APS also could promote the proliferation and differentiation of BFU-E,CFU-E,CFU-GM and CFU-Mix in the human being. The biological mechanism may be that APS can directly and/or indirectly induce bone marrow stromal cell in hematopoietic inductive microenvironment to express IL-3,GM-CSF and so on, then to promote human early hematopoiesis. But now there was no report about mobilization of APS on peripheral blood hematopoietic stem cell.In the past few years,hematopoietic stem cell transplantation(HSCT)...