In Vitro Proliferation Of Human Umbilical Cord Blood Mesenchymal Stem Cells And The Effects On Angiogenesis After Transplantation Into The HIBD Rat Brain

[Background] Hypoxic-ischemic brain damage(HIBD) is one the major factors to make the newborn handicapped. The mortality and handicapped rate is about 47%. 1/3 of the HIBD survival have some different sequelae in central neural system(CNS). For the limitation of regeneration of neural cells, the therapy of HIBD is the most difficult so far since along. Recently, some studies found that the mesenchymal stem cells(MSCs) from blood system have unbelievable plasticity, and can differentiate into bone, cartilage, fat, muscle, even neural cells. Mesenchymal stem cells from bone marrow and umbilical cord blood are the promising cells resourses for brain damage treatment. So, the repairing value of the MSCs in HIBD becoming a hot point. Several papers suggest that MSCs transplantation can improve the HIBD rats physical and mental function, and can express some antigen of CNS cells in the animal brain. A lot of progress have been made in the MSCs research, however there are still many...