The Effect Of Advanced Oxidation Protein Products On Nitric Oxide Production In Mouse Peritoneal Macrophages

BackgroundAtherosclerosis (AS) is one of the major complications of chronic renal failure (CRF). The incidence of AS in CRF is markedly higher than that in general population and the age of incidence is shortened to 30-40 years. So AS in CRF has been termed "accelerated AS" (AAS). The mechanism of the development of AAS in CRF is not clear yet. Previous study has showen oxidative stress, resulting from a disruption of the natural balance between pro-and anti-oxidant systems occurred in CRF patients. In hemodialysis patients, recurrent blood interaction with bioincompatible dialysis membranes or contaminated endotoxin in dialysate triggers polymorphonuclear neutrophil (PMN) and monocyte activation and their subsequent generation of highly reactive oxygen species (ROS). ROS may oxidatively modify low density lipoprotein (LDL) to form oxidized LDL (Ox-LDL) which has been considered to be the key factor in the development of AS. Recent evidences showed that the level of oxidative stress already elevated in mild and moderate CRF patients, which might be caused by accumulated uremic toxins. Advanced oxidation protein products (AOPP) are one of those important macromolecule uremic toxins found recent years. AOPP was found to be elevated in the plasma of CRF patients by...