Studies On Microemulsion Formulation For The Delivery Of A Combination Of Tanshiones And Salvianolic Acids

Salviae miltiorrhizae radix, a traditional Chinese herb with the function of promoting blood flow and removing blood stasis, has been generally applied to cure cardiovascular disease and cerebrovascular disease. The main active components are water-soluble salvianolic acids (Sals) and liposoluble tanshinones (Tans). Both Sals and Tans have showed antiplatelet aggregative activity, antioxidation, anti-artherosclerosis, anti-thromb, reducing myocardial consumption of oxygen (MCO) , diminishing the myocardial infarction size and prevention and cure of myocardial ischemia. Recently, it was reported that all of the different proportions of salvianolic acid B and tanshinone II_A could improve the activity of cordis capillary vessel endothelial cells, degrade the lever of LDH, depress the release of NO and the externalization of ET, when the rat cadiocyte was injuried by oxygen deficiency. Furthermore, the effect of salvianolic acid B (SalB) and tanshinone Il_A(TanII_A) combination was more obvious than that of either salvianolic acid B or tanshinone II_A alone. However, characterized by the structure of ortho-chinone or para-chinone, Tanshinones are hydrophobic which leads to low bioavailability.Microemulsions, typically consisting of an aqueous phase, an organic phase, and a surfactant/cosurfactant component, as a new drug delivery system, have been shown...