Research On The Application Of Transcervical Cells In Genetic Diagnosis During Early Pregnancy

Up to May 31, 2006, 16811 types of genetic diseases have been included in OMIM. Genetic disease and congenital disease account for 0.6% in population measurement. We still have no effective method to treat most of these diseases. Some chromosomal disorder, sex-linked inheritance diseases, genetic metabolic defects and congenital malformations can be diagnosed by prenatal diagnosis. In order to prevent the main genetic diseases which influence life and quality of life severely, we diagnose embryo or fetus with diseases through genetic counseling and terminate pregnancy in time. Non- or micro-invasive prenatal diagnosis became the highlight in perinatology and genetics.The frequently used non-invasive methods for prenatal diagnosis in clinic are as followed: â‘ The fetal nucleated cells isolated from maternal blood was reported to be used for prenatal diagnosis in recent years. But the fetal nucleated cells are microcrystalline and hard to be isolated, which restricts its application. Moreover, the fetal nucleated cells may keep on existing to next pregnancy. â‘¡Some researchers reported that detection of fetal DNA in maternal plasma made it possible to prenatal diagnosis. But these free fragments don't carry intact genetic information and its content in Down syndrome pregnancy still contradictory in many reports â‘¢...