Effects Of Peritoneal Dialysis Solutions Containing Glucose On Phenotype Of Rat Peritoneal Mesothelial Cells In Vitro

BackgroundRecently studies suggested that peritonitis occurred repeatedly and the physiological incompatibility of peritoneal dialysis solutions(PDS) were the two main factors leading to peritoneal fibrosis. Generally, peritoneum has comparatively strong self-repairing capability, so that under the most probable condition the inflammatory exudate can be cleared, and not to change its formation and morphous. But long term peritoneal dialysis(PD) complicating diffuse peritonitis is easy to proceed peritoneal fibrosis, which may be incriminated to tissue damage by inflammatory reaction and the physiological incompatibility of peritoneal dialysis solutions. With the improvement of the means and materials for peritoneal dialysis ,it is mostly the PDS physiological incompatibility but not peritonitis that cause the abortion of PD. The incompatibility of PDS includes low PH,hypertonia,high glucose and lactate balanced solution, et al, and high glucose is the most important factor. The concentration of glucose in PDS is 14-40 times higher than normal in body, and peritoneal mesothelial cells which are the main cells cover peritoneum are soaked in this kind of solutions.