| Vitamin E nicotinate (VEN), an activator of microcirculation, had considerable effectiveness for therapying arteriosclerosis, cerebral apoplexy, post-traumatic brain syndrome, hyperlipemia, hypertension, and central retentions. Because of the poor solubility in water, VEN had low absorption in vivo from the capsules, soft capsules and granules in market in nowadays. Self-emulsifying drug delivery system (SEDDS) was selected as the carrier to prepare soft capsules to enhance absorption of VEN in this work.The solubility of VEN in various excipients and the interaction between all kinds of oils and surfactants were investigated. According to the results, the surfactants that had considerable emulsifying ability, the oils and the cosurfactants that were able to solute more drugs and had low viscosity were selected to screen the basic formula.In order to assay in vitro release and concentration in plasma in vivo of VEN, a high-performance liquid chromatography was developed. A good specificity, sensitivity and reproducibility of this method make it particularly suitable for routine determination of VEN.Olive Oil, ethyl oleate and Labrafac were used as oils. Labrasol, Tween80 and EL-20 were selected as surfactants. 1,2-propanol, transcutol and labrafil were used as cosurfactants. The experiments based on orthogonal design were carried out. Pseudo-ternary phase diagrams were constructed to identify the efficient self-emulsification region. The basic formulation which had the biggest efficient self-emulsification region was ethyl oleate / EL-20 / transcutol. The effects of oils, surfactants, cosurfactants, VEN, solution, temperature and dispersed methods on...
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