The Research Of Smedds Capsule Of α-asarone

α-asarone(ARE) is a drug which has poor water solubility and the delivery of such drug is frequently associated with implication of low bioavailability. To overcome the problem, the self-microemulsifying drug delivery system(SMEDDS) of ARE was investigated which can markedly improve the dissolution and bioavailability of ARE.The saturated solubility of ARE was determined in various oils, surfactants and cosurfactants. Some oils, surfactants and cosurfactants which can solve ARE well were creened. On the base of these investigation, the pseudo-ternary phase diagrams were constructed identifying the efficient self-microemulsification regions. The phase diagrams, the results of droplet size analysis of the formulations upon their addition to water under mild agitation conditions were compared. Efficient and better self-microemulsification processes were observed. From these studies, an optimized formulation consisting of ARE(6%), EthylOleate(26), Tween80(50) and PEG400(18) was selected.The in vitro analysis method was studied and UV method was adapted to determine the dissolution of SMEDDS capsules and control tablets, the stability-testing after self-microemulsification. The dissolution of SMEDDS capsules in 3 kinds of media were investigated and drawed a conclusion by calculating the analogical factors(f) that there was no difference among the three dissolution curves. Meanwhile by the comparison of the difference of dissolution curves between SMEDDS capsule and control tablets, the...