Studies On The Acyclovir Submicroemulsion For Injection Administration

Acyclovir(ACV), an antiviral agent of nucleoside,has highly selective activity against virus infective cells and virtually non-toxic to human normal cells. It can effectively suppress the duplication of various DNA in host cells. Acyclovir has been widely used clinically as the first picked medicine to restrain the herpes simplex virus Type-â… , Type- â…¡ (HSV- â… , â…¡) and varicella-zoster virus infections. However , because of its poor solubility in water, the half-life time for injection is 2.9 hours, the plasma protein binding rate is 9%-30%. The purpose of the present study was to enhance the absorption of acyclovir and improve its bioavailability.The main goal of this paper was to prepare acyclovir submicro-pharmacy and to investigate the physico-chemical characteristics of them , the efficacy in vivo, pharmacokinetics and bioavai lability relative to sc. This paper included some works are as followings: Natural lipid used as a vehicle, the acyclovir submicro-pharmacy was prepared by a trituration-emulsification procedure, stability constant, sedimentation volume ratio, and the result of submicroscope were used as indexes, orthogonal design experiments were performed to optimize the conditions for the process. The surface morphology and particle size...