The Effect Of Milrione On Gastrointestinal Aerobic Metabolism During SMAO Shock Rabbits

Objective: Milrione is an inhibitor of PDE_â…¢, which has shown potentially favourable hemodynamic responses, the total oxygen Deliver (DO₂) , Oxygen Consumption (VO₂), Oxygen extraction ratio(O₂ER) and the Oxygen derived free radicals . But the effect of milrione on intestinal aerobic metabolism was few report.The present study was therefore undertaken to investigate these problems in SMAO shock rabbits.Methods: Sixteen healthy rabbits were duplicated the SMAO shock model, then randomly divided them into two group(n=8): group A was control group; group B was remedied group, 50ug.kg^-1 of milrione was infused and then continuously being pouring in milrione 0.5 ug.kg^-1min^-1 while removing artery clamp.During the experiment, we observed the arterial blood stream amount(SMAF) on the mesentery , MAP, HR, arterial, venous blood gas analysis and plasma MDA at before shock(-1h), 0h, 1h, 2h; calculated DO₂, VO₂,O₂ER by formula.Results: After removed artery clamp the MAP, HR and SMAF of A and B groups were lower than -1h (P<0.05 或<0.01) ,which meaned that the shock model was duplicated successfully.During the 1-2 hours after removed artery clamp,compared with group A the MAP, HR , SMAF, DO₂ and VO₂ were increased(P<0.05 或<0.01), O₂ER were not changed noticeably(P>0.05), plasma MDA were decreased(P<0.05).Conclusion: In SMAO shock rabbits, Milrione can considerably increase SMAF , DO₂, VO₂ and blood pressure, decrease the plasma MDA, it may be beneficial to the treateamt of shock. But O₂ER were not changed noticeably.