Effects And Mechanism Of Rosiglitazone On Angiotensin â…¡-induced Hypertension

Objective: The thiazolidinediones such as rosiglitazone have been reported to yield cardiovascular benefits in patients by a mechanism that is not completely understood. We tested the hypothesis that rosiglitazone treatment would prevent some of the effects of Ang Ⅱ by antioxidative effect. Methods: Sprague-Dawley rats received Ang Ⅱ (300 ng/kg/min) subcuta-neously, osmotic pump)with or without rosiglitazone (5 mg/kg/d) for 7 days. In addition, rosiglitazone was also given in sham-operated rats. The systolic BP, the heart weight index values, vascular superoxide anion production and NADPH oxidase activity were determined.Results: Systolic BP, elevated in Ang Ⅱ -infused rats, was reduced by rosiglitazone (136±6mmHg vs. 166±6mmHg).and the heart weight index values were reduced (3.54±0.04mg/g vs. 3.85±0.08mg/g) .Rosiglitazone treatment of Ang II -infused rats inhibited vascular superoxidase production and NADPH oxidase activity(p<0.01)Conclusions: These results indicate that rosiglitazone may prevent the development of hypertension and myocardial hypertrophy,as well as the Ang Ⅱ -induced increases in NADPH oxidase activity and superoxide anion...